The Black Stars have been tipped to come out on top in this after keeping clean sheets in four of their last five matches. They need to win this one and make the last 16 as anything less than victory could mean an early exit for the 2015 finalists.
Guinea-Bissau did keep a clean sheet against Benin last time out, but they had both their keeper and Benin’s general lack of end-product to thank for that. They have never won a match at the Africa Cup of Nations and they have themselves a tough match against a very experienced Ghana side.
Guinea Bissau are without a win in their last five games whilst Ghana have drawn their last three consecutive fixtures ahead of this meeting. Guinea Bissau have never won a match at the AFCON and you can bet on a Ghana victory at odds of 1.30.
Under 2.5 Goals have been scored in four of Guinea-Bissau's last five games and in three of Ghana's last five outings. This makes Under 2.5 Goals look good at odds of 1.60 here.
Only one of Guinea-Bissau's last five games has seen both teams find the back of the net. The Ghanaians have seen only one team score in three of their last four meetings in all competitions and therefore you can back Both Teams to Score No at odds of 1.35.
Guinea-Bissau could recall Zezinho, who played 90 minutes against Cameroon but missed out against Benin, though wholesale changes aren't expected.
Christian Atsu was forced off early last time out and is thus unlikely to feature on Tuesday. Samuel Owusu is expected to deputise for the Newcastle midfielder.
Guinée-Bissau: Mendes, Djalo, Soares, Mamadu Cande, Nanu, Bura, Pele, Manconi, Mendy, Piqueti, Balde
Ghana: Ofori, Mensah, Kasim, Baba Rahman, Yiadom, Thomas, Wakaso, Asamoah, Owusu, A. Ayew, J. Ayew